High-Fructose Corn Syrup Leads to
Abnormal Weight Gain
Food manufacturers were quick to embrace high-fructose corn syrup or HFCS
when it first appeared in the late sixties. The stuff not only extended the shelf life of
processed foods, it also was cheaper than sugar when used as a sweetener.
But health advocates were also quick to warn about the dangers of high-fructose
corn syrup consumption, especially in the area of weight gain.
Now a new study has given one more reason why we should avoid HFSC like the
plaque.
Researchers from Princeton University found that rats fed with high-fructose corn
syrup gained significantly more weight than those fed with table sugar, even when
their overall caloric intake was the same.
In addition to causing significant weight gain in lab animals, long-term
consumption of high-fructose corn syrup also led to abnormal increases in body
fat, especially in the abdomen, and a rise in circulating blood fats called
triglycerides.
"Some people have claimed that high-fructose corn syrup is no different than other
sweeteners when it comes to weight gain and obesity, but our results make it
clear that this just isn't true, at least under the conditions of our tests," said Prof
Bart Hoebel. who specializes in the neuroscience of appetite, weight and sugar
addiction.
"When rats are drinking high-fructose corn syrup at levels well below those in
soda pop, they're becoming obese -- every single one, across the board. Even
when rats are fed a high-fat diet, you don't see this; they don't all gain extra weight,"
Hoebel said.
The researchers carried out two two experiments to investigate the link between
the consumption of high-fructose corn syrup and obesity.
The first study showed that male rats given water sweetened with high-fructose
corn syrup in addition to a standard diet of rat chow gained much more weight
than male rats that received water sweetened with table sugar, or sucrose, in
conjunction with the standard diet. The concentration of sugar in the sucrose
solution was the same as is found in some commercial soft drinks, while the
high-fructose corn syrup solution was half as concentrated as most sodas.
The second experiment -- the first long-term study of the effects of high-fructose
corn syrup consumption on obesity in lab animals -- monitored weight gain, body
fat and triglyceride levels in rats with access to high-fructose corn syrup over a
period of six months.
Compared to animals eating only rat chow, rats on a diet rich in high-fructose corn
syrup showed characteristic signs of a dangerous condition known in humans as
the metabolic syndrome, including abnormal weight gain, significant increases in
circulating triglycerides and augmented fat deposition, especially visceral fat
around the belly.
Male rats in particular ballooned in size: Animals with access to high-fructose corn
syrup gained 48 percent more weight than those eating a normal diet.
The researchers noted that the rats were not just getting fat but were also
demonstrating characteristics of obesity, including substantial increases in
abdominal fat and circulating triglycerides.
In humans, these same characteristics are known risk factors for high blood
pressure, coronary artery disease, cancer and diabetes.
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