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    Moderate Level of Aerobic Fitness
    Lowers Risk of Stroke

    A large, long-running study has found that a moderate level of aerobic
    fitness can significantly reduce the risk of stroke.

    Steven Hooker, the study's lead author, says fitness has a protective effect
    regardless of the presence or absence of other stroke risk factors,
    including family history of cardiovascular disease, diabetes, high blood
    pressure, elevated cholesterol levels and high body mass index.”

    “This study is the first to suggest that there may be a significant
    independent association between cardio-respiratory fitness (CRF) and
    fatal and nonfatal stroke in men and nonfatal stroke in women,” said
    Hooker, director of the Prevention Research Center at the University of
    South Carolina Arnold School of Public Health, Columbia, S.C.

    About 780,000 U.S. adults suffer a stroke each year, and stroke is a
    leading cause of serious, long-term disability in the United States,
    according to the American Stroke Association.  It’s often fatal, claiming
    about 150,000 lives and ranking as the No. 3 cause of death.

    Researchers analyzed data on more than 60,000 people — 46,405 men
    and 15,282 women who participated in the Aerobics Center Longitudinal
    Study between 1970 and 2001 at the Cooper Aerobics Center in Dallas.  

    The participants, ages 18 to 100 and free of known cardiovascular disease
    when they entered the study, were followed for an average of 18 years.  
    During that time, 863 people — 692 men and 171 women — had strokes.

    Upon entering the study, each participant took a test to measure CRF in
    which they walked on a treadmill at increasing grade and/or speed until
    they reached their maximal aerobic capacity.

    Although previous studies have looked at an association between self-
    reported physical activities and cardiovascular disease, few have used
    direct measurements such as the CRF measure used in this study,
    Hooker said.   This is also the first study to explore the association
    between CRF and risk of stroke in women.

    Men in the top quartile (25 percent) of CRF level had a 40 percent lower
    relative risk of stroke compared to men in the lowest quartile.  That inverse
    relationship remained after adjusting for other factors such as smoking,
    alcohol intake, family history of cardiovascular disease, body mass index
    (an estimation of body fatness), high blood pressure, diabetes and high
    cholesterol levels, he said.

    Among women, those in the higher CRF level had a 43 percent lower
    relative risk than those in the lowest fitness level.

    The overall stroke risk dropped substantially at the moderate CRF level,
    with the protective effect persisting nearly unchanged through higher
    fitness levels.   That corresponds to 30 minutes or more of brisk walking,
    or an equivalent aerobic activity, five days a week.

    “We found that a low-to-moderate amount of aerobic fitness for men and
    women across the whole adult age spectrum would be enough to
    substantially reduce stroke risk,” Hooker said.

    “Although stroke death rates have declined over the past few decades, the
    public health burden of stroke-related disabilities continues to be large
    and may even increase in coming years, as the population ages.”

    Physical activity is a major modifiable cardiovascular disease risk factor.  
    Increasing the nation’s CRF through regular physical activity could be a
    vital weapon to lower the incidence of stroke in men and women, he said.

    One of the study’s limitations is that most of the participants were white,
    well-educated and middle-upper income, he said.  He recommended that
    data be collected from other populations.

    The findings were presented at the American Stroke Association’s
    International Stroke Conference 2008.
 
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